Frizzled definitions
| Word backwards | delzzirf |
|---|---|
| Part of speech | The word "frizzled" can be used as both a verb and an adjective. In its verb form, it is the past tense of the verb "frizzle," meaning to cook or brown by frying or grilling. In its adjective form, it describes something that is cooked or browned in this way. |
| Syllabic division | friz-zled |
| Plural | The plural form of the word frizzled is frizzles. |
| Total letters | 8 |
| Vogais (2) | i,e |
| Consonants (5) | f,r,z,l,d |
Frizzled is a family of proteins that play a critical role in the Wnt signaling pathway. This pathway is essential for various developmental processes in animals, including cell proliferation, differentiation, and migration. The frizzled proteins act as cell surface receptors for Wnt ligands, transmitting signals from outside the cell to the inside.
Structure of Frizzled Proteins
Frizzled proteins are characterized by a seven-pass transmembrane domain structure, which allows them to span the cell membrane. They also contain a cysteine-rich domain that is involved in binding Wnt ligands. Frizzled proteins come in various isoforms, each with slightly different structures that may lead to unique functional roles.
Function of Frizzled Proteins
Frizzled proteins are known to activate the Wnt signaling pathway upon binding to Wnt ligands. This activation leads to the stabilization and nuclear translocation of β-catenin, a key transcriptional regulator. The downstream effects of Wnt signaling can vary depending on the cell type and context, influencing processes such as cell fate determination, tissue regeneration, and embryonic development.
Implications in Disease
Aberrant regulation of the Wnt signaling pathway, including dysregulation of frizzled proteins, has been associated with various human diseases. For example, mutations in frizzled genes have been linked to certain types of cancer, where uncontrolled Wnt signaling can promote tumor growth and metastasis. Understanding the role of frizzled proteins in disease pathology may offer novel therapeutic targets for intervention.
Frizzled proteins continue to be a focus of research in the fields of developmental biology, cancer biology, and regenerative medicine. Their intricate involvement in the Wnt signaling pathway highlights their significance in diverse biological processes.
Overall, frizzled proteins serve as crucial mediators of Wnt signaling, translating extracellular signals into intracellular responses that regulate gene expression and cellular behavior. The complexity of their functions underscores the importance of further exploring their roles and potential therapeutic implications.
Frizzled Examples
- Her hair was frizzled from the humidity.
- The frizzled edges of the paper gave it a vintage look.
- The chef frizzled the onions to top the dish.
- After using the wrong hair product, her hair became frizzled.
- The frizzled wires needed to be replaced in the old lamp.
- The heat from the grill caused the edges of the meat to become frizzled.
- She decided to frizzle the bacon for added crispiness.
- The frizzled paint on the fence needed a fresh coat.
- The frizzled appearance of the dress made it look more casual.
- The frizzled pattern in the fabric added a unique texture to the design.